Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Khetan, Prerna, Boffetta, Paolo, Luce, Daniele, Stucker, Isabelle, Curado, Maria Paula, Menezes, Ana, Wunsch-Filho, Victor, Ahrens, Wolfgang, Lagiou, Pagona, Serraino, Diego, Richiardi, Lorenzo, Kjaerheim, Kristina, Conway, David, Thomson, Peter, Muscat, Joshua, Mates, Dana, Ramroth, Heribert, Menvielle, Gwenn, Vaughan, Thomas L., Brenner, Hermann, Lee, Yuan Chin Amy, La Vecchia, Carlo, Hashibe, Mia, and Hashim, Dana (2019) Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. Journal of Occupational and Environmental Medicine, 61 (5). pp. 397-404.

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Abstract

Objective: To investigate the associations between head and neck cancer (HNC) risk and occupations.

Methods: We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.

Results: Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.

Conclusions: We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.

Item ID: 68445
Item Type: Article (Research - C1)
ISSN: 1536-5948
Keywords: Cancer, Head, Larynx, Neck, Occupation, Pooled
Copyright Information: © 2019 American College of Occupational and Environmental Medicine.
Date Deposited: 02 Aug 2022 01:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320305 Oral and maxillofacial surgery @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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