“Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection

Adeoye, John, Brennan, Peter A., and Thomson, Peter (2020) “Search less, verify more”—Reviewing salivary biomarkers in oral cancer detection. Journal of Oral Pathology & Medicine, 49 (8). pp. 711-719.

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Oral squamous cell carcinoma is one of the commonest head and neck malignancies with approximately 350 000 cases reported annually and a mortality rate of 50% often attributed to late clinical presentation. Due to the close relationship between saliva bio-fluid and tumour lesions, optimizing salivary biomarkers for disease detection and screening provides a major new research direction in diagnostic oral oncology. As inter-tumour heterogeneity and intra-tumour heterogeneity are common within oral cavity neoplasms, it is unlikely that a single diagnostic or “risk-stratifying” saliva biomarker will suffice for universal translation to clinical practice. Therefore, this article highlights a number of promising saliva biomarker combinations for oral cavity cancer detection that require further research and validation to determine their true diagnostic potential.

Item ID: 68434
Item Type: Article (Research - C1)
ISSN: 1600-0714
Keywords: biomarkers, oral squamous cell carcinoma, saliva
Copyright Information: © 2020 John Wiley & Sons A/S
Date Deposited: 01 Aug 2022 06:15
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320307 Oral medicine and pathology @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321102 Cancer diagnosis @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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