Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case–control studies within the INHANCE Consortium

Conway, David I., Hovanec, Jan, Ahrens, Wolfgang, Ross, Alastair, Holcatova, Ivana, Lagiou, Pagona, Serraino, Diego, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, MacFarlane, Gary J., Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Brennan, Paul, Luce, Danièle, Menvielle, Gwenn, Stucker, Isabelle, Benhamou, Simone, Ramroth, Heribert, Boffetta, Paolo, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander, Koifman, Rosalina, Wunsch-Filho, Victor, Yuan-Chin, Amy Lee, Hashibe, Mia, Behrens, Thomas, and McMahon, Alex D. (2021) Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case–control studies within the INHANCE Consortium. Journal of Epidemiology & Community Health, 75 (8). pp. 779-787.

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Abstract

Background: The association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.

Methods: Pooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.

Results: For the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).

Conclusions: These findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.

Item ID: 68423
Item Type: Article (Research - C1)
ISSN: 1470-2738
Keywords: cancer epidemiology; cancer: occupational; socioeconomic
Copyright Information: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Funders: European Community (5th Framework Programme) (ECFP), Swiss League against Cancer (SLAC), Fribourg League against Cancer (FLAC), Swiss Cancer Research (SCR), Gustave-Roussy Institute (GRI), German Ministry of Education and Research (FKZ), Fondo para la Investigación Cientifica y Tecnológica (FONCyT), IMIM Hospital del Mar Medical Research Institute (Barcelona), Fundaco de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP), European Commission (EC), National Cancer Institute (NCI), National Institute of Dental and Craniofacial Research (NIDCR), French National Research Agency (ANR), French National Cancer Institute, French Agency for Food, Environmental and Occupational Health and Safety, French Institute for Public Health Surveillance, Fondation pour la Recherche Médicale (FRM), Fondation de France, Fondation ARC pour la Recherche sur le Cancer, French Ministry of Labour (Direction Générale du Travail), French Ministry of Health(Direction Générale de la Santé)
Projects and Grants: ECFP grant no QLK1-CT-2001-00182, SLAC grant KFS1069-09-2000, FLAC grant FOR381.88, SCR grant (AKT617), GRI grant 88D28, FKZ grant 01GB9702/3, FAPESP grant 01/01768-2, EC grant IC18-CT97-0222, NCI grant R03CA113157, NIDCR grant R03DE016611
Date Deposited: 14 Sep 2021 01:18
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2004 Public health (excl. specific population health) > 200499 Public health (excl. specific population health) not elsewhere classified @ 100%
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