Statistical profiling of oral cancer and the prediction of outcome

Wang, Weilan, Adeoye, John, Thomson, Peter, and Choi, Siu Wai (2021) Statistical profiling of oral cancer and the prediction of outcome. Journal of Oral Pathology and Medicine, 50 (1). pp. 39-46.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: https://doi.org/10.1111/jop.13110
 
18
1


Abstract

Background: The global burden of oral squamous cell carcinoma (OSCC) remains formidable. Identifying factors predictive of aggressive tumour behaviour, disease progression and reduced survival time may assist in early identification of “high-risk” patients and appropriately target combination cancer therapies.

Methods: A retrospective review of 467 OSCC patients treated over a 19-year period facilitated detailed clinico-pathological database analysis and determination of clinical outcome categories based upon time to progressive disease (loco-regional tumour recurrence and/or distant metastasis), overall death and OSCC-related death (death directly attributable to OSCC). Odds ratio (OR) and hazard ratio (HR) statistical measures were used to investigate relationships between patient demographics and clinico-pathological tumour features with clinical outcome.

Results: Older age at presentation (P =.002) and a history of previous non–head and neck cancer (P =.010) increased the risk of overall death. OR for progressive disease development (P =.008) and OSCC-related death (P =.019) was most significant for buccal tumours. HR confirmed advanced-stage disease increased the risk of progressive disease (P <.001), overall death (P <.001) and OSCC-related death (P <.001). Positive resection margins were associated with a higher risk of OSCC-related death (P =.023). Significantly lower risks of progressive disease development (P =.002) and OSCC-related death (P =.012) were seen in patients undergoing neck dissection, whilst combination chemoradiotherapy reduced HR for overall death (P <.001) and OSCC-related death (P =.011).

Conclusion: Statistical profiling of OSCC clinico-pathological data identifies significant influences on clinical outcome. This study adds evidence to the hypothesis that buccal SCC displays aggressive tumour behaviour and poor clinical outcome.

Item ID: 68418
Item Type: Article (Research - C1)
ISSN: 1600-0714
Keywords: oral cancer, oral mucosa
Copyright Information: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Date Deposited: 28 Jun 2021 22:08
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320305 Oral and maxillofacial surgery @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321109 Predictive and prognostic markers @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page