Comparative evaluation of lumpy skin disease virus-based live attenuated vaccines

Haegeman, Andy, De Leeuw, Ilse, Mostin, Lauren, Campe, Willem Van, Aerts, Laetitia, Venter, Estelle, Tuppurainen, Eeva, Saegerman, Claude, and De Clercq, Kris (2021) Comparative evaluation of lumpy skin disease virus-based live attenuated vaccines. Vaccines, 9 (5). 473.

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Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.

Item ID: 68000
Item Type: Article (Research - C1)
ISSN: 2076-393X
Keywords: lumpy skin disease; vaccine evaluation; live attenuated vaccines; lumpy skin disease vaccine
Copyright Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Funders: Bill and Melinda Gates Foundation (BMGF), GALVmed, Belgian Federal Public Service of Health (BFPS), Food Chain Safety and Environment
Projects and Grants: BMGF OPP1126866, GALVmed CAO-R34A0856, BFPS RT 15/3 (LUMPY SKIN 1)
Date Deposited: 14 Jun 2021 06:01
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300914 Veterinary virology @ 100%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280101 Expanding knowledge in the agricultural, food and veterinary sciences @ 100%
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