Monoclonal gammopathy of renal significance triggering atypical haemolytic uraemic syndrome

Mahmood, Usman, Isbel, Nicole, Mollee, Peter, Mallett, Andrew, Govindarajulu, Sridevi, and Francis, Ross (2017) Monoclonal gammopathy of renal significance triggering atypical haemolytic uraemic syndrome. Nephrology, 22 (Suppl. 1). pp. 15-17.

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Haemolytic uraemic syndrome is a rare condition with an overall incidence ofone to two cases in a population of 100 000 and approximately 10% of thesecases are classified as atypical.1Atypical haemolytic uraemic syndrome (aHUS)is a thrombotic microangiopathy (TMA) characterized by microangiopathichaemolytic anaemia (MAHA), thrombocytopenia and acute kidney injury.aHUS can be genetic, acquired or idiopathic (negative genetic screening andno environmental triggers). We describe a case of aHUS triggered by monoclo-nal gammopathy of renal significance (MGRS) successfully treated with plas-mapheresis and a bortezomib-based chemotherapy regimen, resulting inmarked improvement in renal function and other markers of haemolysis. Thispatient has been in remission for more than 2 years currently.

Item ID: 67884
Item Type: Article (Case Study)
ISSN: 1440-1797
Copyright Information: © 2017 Asian Pacific Society of Nephrology
Date Deposited: 15 Jul 2021 00:19
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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