Pilot clinical and validation study of the PROPKD score in clinical practice amongst patients with Autosomal Dominant Polycystic Kidney Disease

Chan, Samuel, Patel, Chirag, and Mallett, Andrew (2020) Pilot clinical and validation study of the PROPKD score in clinical practice amongst patients with Autosomal Dominant Polycystic Kidney Disease. Nephrology, 25 (2). pp. 274-275.

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DOI: 10.1111/nep.13640

View at Publisher Website: https://doi.org/10.1111/nep.13640

Abstract

[Extract] Worldwide, Autosomal Dominant Polycystic Kidney Disease (ADPKD) affects approximately 4–7 million individuals and accounts for 10% of patients receiving renal replacement therapy. Recently, the PROPKD score was developed from the GENKYST cohort to stratify risk of progression to end-stage kidney disease (ESKD) in patients with ADPKD, based on gender, hypertension <35 years, urological event <35 years and causative PKD1 or PKD2 genotype. The PROPKD score showed significant differences in kidney survival between ADPKD patients who were low risk (0–3 points), intermediate risk (4–6 points) and high risk (>6 points) in terms of progression to ESKD.


Item ID:	67863
Item Type:	Article (Short Note)
ISSN:	1440-1797
Copyright Information:	© 2019 The Authors. Nephrology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Nephrology.
Date Deposited:	05 Jul 2022 22:04
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320213 Medical genetics (excl. cancer genetics) @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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