Biodegradation behavior of micro-arc oxidation coating on magnesium alloy-from a protein perspective

Zhang, Zhao-Qi, Wang, Li, Zeng, Mei-Qi, Zeng, Rong-Chang, Kannan, M. Bobby, Lin, Cun-Guo, and Zheng, Yu-Feng (2020) Biodegradation behavior of micro-arc oxidation coating on magnesium alloy-from a protein perspective. Bioactive Materials, 5 (2). pp. 398-409.

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Protein exerts a critical influence on the degradation behavior of absorbable magnesium (Mg)-based implants. However, the interaction mechanism between protein and a micro-arc oxidation (MAO) coating on Mg alloys remains unclear. Hereby, a MAO coating was fabricated on AZ31 Mg alloy. And its degradation behavior in phosphate buffer saline (PBS) containing bovine serum albumin (BSA) was investigated and compared with that of the uncoated alloy. Surface morphologies and chemical compositions were studied using Field-emission scanning electron microscope (FE-SEM), Fourier transform infrared spectrophotometer (FT-IR) and X-ray diffraction (XRD). The degradation behavior of the bare Mg alloy and its MAO coating was studied through electrochemical and hydrogen evolution tests. Cytotoxicity assay was applied to evaluate the biocompatibility of Mg alloy substrate and MAO coating. Results indicated that the presence of BSA decreased the degradation rate of Mg alloy substrate because BSA (RCH(NH2)COO‾) molecules combined with Mg2+ ions to form (RCH(NH2)COO)2Mg and thus inhibited the dissolution of Mg(OH)2 by impeding the attack of Cl‾ ions. In the case of MAO coated Mg alloy, the adsorption of BSA on MAO coating and the formation of (RCH(NH2)COO)2Mg exhibited a synergistic effect and enhanced the corrosion resistance of the coated alloy significantly. Furthermore, cell bioactive assay suggested that the MAO coating had good viability for MG63 cells due to its high surface area.

Item ID: 67186
Item Type: Article (Research - C1)
ISSN: 2452-199X
Keywords: Biocompatibility, Degradation, Magnesium alloy, Micro-arc oxidation, Protein
Copyright Information: © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (
Funders: National Natural Science Foundation of China (NNSFC), Shandong University of Science and Technology (SDUST)
Projects and Grants: NNSFC 51571134, SDUST Research Fund 2014TDJH104
Date Deposited: 28 Apr 2021 22:34
FoR Codes: 40 ENGINEERING > 4003 Biomedical engineering > 400302 Biomaterials @ 100%
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