Use of regional administration of prophylactic antibiotics in total knee arthroplasty

Symonds, Tristan, Parkinson, Ben, Hazratwala, Kaushik, McEwen, Peter, Wilkinson, Matthew, and Grant, Andrea (2018) Use of regional administration of prophylactic antibiotics in total knee arthroplasty. ANZ Journal of Surgery, 88 (9). pp. 848-853.

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Abstract

Prosthetic joint infection after total knee arthroplasty is an infrequent, yet serious complication. Antimicrobial prophylaxis plays an important role in reducing the rate of surgical site infections. To be effective as an antimicrobial prophylaxis, the serum, tissue and bone concentrations of the antibiotic must be greater than the target organism's minimum inhibitory concentration. As antibiotic resistance increases current intravenous prophylactic dosing has been shown to be subtherapeutic for some patients. Intravenous regional administration and intraosseous regional administration of prophylactic antibiotics are novel methods used to increase the antibiotic tissue concentrations, which may enhance the efficacy of prophylactic antibiotics in total knee arthroplasty. Currently, literature has shown both intravenous regional administration and intraosseous regional administration to be safe and effective techniques. However, there is no clinical evidence to show that it results in a reduction of prosthetic joint infection rates. This study summarizes the current knowledge base on the use of regional administration of prophylactic antibiotics in total knee arthroplasty.

Item ID: 67111
Item Type: Article (Research - C1)
ISSN: 1445-2197
Copyright Information: © 2018 Royal Australasian College of Surgeons
Date Deposited: 22 Sep 2021 00:17
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320216 Orthopaedics @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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