Association of gout with major adverse cardiovascular events and all-cause mortality in patients with peripheral artery disease

Singh, Tejas P., Wong, Shannon, Quigley, Frank, Jenkins, Jason, and Golledge, Jonathan (2020) Association of gout with major adverse cardiovascular events and all-cause mortality in patients with peripheral artery disease. Atherosclerosis, 312. pp. 23-27.

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Abstract

Background and aims: Prior epidemiological studies have suggested that individuals with gout are at greater risk of cardiovascular events, but there have been no studies in people with peripheral artery disease (PAD). The aim of this study was to investigate the relationship between gout and major adverse cardiovascular events (MACE) and all-cause mortality in people with PAD.

Methods: Participants with a range of PAD presentations, including carotid artery disease, aortic or peripheral aneurysm and lower limb PAD, were prospectively recruited from outpatient vascular departments within Australia. MACE (myocardial infarction, stroke or cardiovascular death) and all-cause mortality were identified through out-patient follow-up and linked medical records. Propensity-score matching was undertaken to generate a matched cohort of patients with and without a history of gout. Kaplan-Meier survival analysis and Cox-proportional hazard analysis were used to examine the association of gout with MACE and all-cause mortality.

Results: A total of 4308 people with PAD, of whom 334 had a history of gout, were included and followed for a median (inter-quartile range) of 2.1 (0.1-5.9) years. In the unadjusted analyses, participants with gout were at increased risk of MACE (hazard ratio, HR 1.37, 95% confidence intervals, CI 1.09-1.71, p = 0.006) and all-cause mortality (HR 1.38, 95% 1.13-1.68, p = 0.002), however, the associations were lost in the adjusted analyses. In the propensity-score matched cohort, gout was not significantly associated with an increased risk for MACE or all-cause mortality.

Conclusions: Gout was not independently associated with increased cardiovascular events in PAD patients.

Item ID: 67085
Item Type: Article (Research - C1)
ISSN: 1879-1484
Keywords: Gout; Major cardiovascular events; Peripheral artery disease
Copyright Information: © 2020 Elsevier B.V. All rights reserved.
Funders: National Health and Medical Research Council (NHMRC), Queensland Government (QG)
Projects and Grants: NHMRC grant 1117061, QG Senior Clinical Research Fellowship, QG Junior Doctor Research Fellowship
Date Deposited: 09 Mar 2021 04:11
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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