Risk factors and mouse models of abdominal aortic aneurysm rupture

Krishna, Smriti Murali, Morton, Susan K., Li, Jiaze, and Golledge, Jonathan (2020) Risk factors and mouse models of abdominal aortic aneurysm rupture. International Journal of Molecular Sciences, 21 (19). 7250.

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Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Previous research suggests that aortic wall structure and strength, biomechanical forces on the aorta and cellular and proteolytic composition of the AAA wall influence the risk of AAA rupture. Mouse models offer an opportunity to study the association of these factors with AAA rupture in a way not currently possible in patients. Such studies could provide data to support the use of novel surrogate markers of AAA rupture in patients. In this review, the currently available mouse models of AAA and their relevance to the study of AAA rupture are discussed. The review highlights the limitations of mouse models and suggests novel approaches that could be incorporated in future experimental AAA studies to generate clinically relevant results.

Item ID: 66818
Item Type: Article (Research - C1)
ISSN: 1422-0067
Keywords: abdominal aortic aneurysm; aneurysm rupture; aortic stiffness; peak wall stress; preclinical imaging; rupture risk.
Copyright Information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Funders: National Health and Medical Research Council of Australia (NHMRC)., Queensland Government (QG), College of Medicine, James Cook University (JCU)
Projects and Grants: NHMRC 079369, NHMRC 1079193, NHMRC 109871, NHMRC Practitioner Fellowship 1117061, QG Senior Clinical Research Fellowship
Date Deposited: 02 Mar 2021 01:50
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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