Cystatin C: a more reliable biomarker of renal function in young infants? A longitudinal cohort study

Kandasamy, Yogavijayan, and Rudd, Donna (2021) Cystatin C: a more reliable biomarker of renal function in young infants? A longitudinal cohort study. Acta Paediatrica. (In Press)

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Abstract

Aim: We carried out a longitudinal cohort study to measure serial CysC (Cystatin C) in a cohort of neonates born preterm until the age of 2 years. We hypothesised that CysC levels are independent of body weight and would not vary with gestational age.

Methods: This prospective cohort study was conducted from August 2014 until October 2016, and follow-up was completed in October 2018. Preterm infants at less than 28 weeks of gestation (extremely preterm infants) were recruited and followed up until the age of 24 months. Blood samples for measurement of CysC were collected at regular intervals.

Results: We recruited 58 preterm neonates with mean gestation was 26.2 (1.5) weeks, and a mean birth weight was 917 (140) g. One-way analysis of variance (ANOVA) did not show any significant difference in CysC levels between 28, 32 and 37 weeks' gestation (P = .09) despite a significant increase in body weight (P < .001). The mean CysC level was higher in the neonatal period and subsequently plateaued by 24 months.

Conclusion: Serum CysC level is independent of body weight and not influenced by postnatal age nor by gender.

Item ID: 66272
Item Type: Article (Research - C1)
ISSN: 1651-2227
Keywords: biomaker, Cystatin C, preterm infant, renal
Copyright Information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
Funders: National Health and Medical Research Council (NHMRC)
Date Deposited: 02 Mar 2021 23:22
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320202 Clinical chemistry (incl. diagnostics) @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321303 Neonatology @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
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