A retrospective analysis of the prevalence and clinical outcomes of vitamin D deficiency in myeloma patients in tropical Australia

Nath, Karthik, Ganeshalingam, Vibooshini, Ewart, Barbara, Heyer, Elizabeth, Watt, Kerrianne, Birchley, Andrew, Casey, John, Lai, Hock-Choong, Morris, Edward, and Hodges, Georgina (2020) A retrospective analysis of the prevalence and clinical outcomes of vitamin D deficiency in myeloma patients in tropical Australia. Supportive Care in Cancer, 28. pp. 1249-1254.

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Abstract

Purpose

The aim of this descriptive study was to assess the prevalence of vitamin D deficiency in patients on active therapy for multiple myeloma in a tropical climate. We also tested for the association of vitamin D status on clinical outcomes.

Methods

This was a single centre, observational study performed in Townsville, Australia, which has a sunlight heavy, tropical climate. Patients on active therapy for multiple myeloma underwent testing of serum 25-hydroxyvitamin D (25(OH)D). Information on disease stage, skeletal morbidity and symptoms of peripheral neuropathy were collected from medical records and self-reported patient questionnaires.

Results

A total of 41 patients were included. With a median disease duration of 38 months, 27% were found to be vitamin D deficient. Patients with vitamin D deficiency had a higher likelihood of peripheral neuropathy compared with their non-vitamin D counterparts (73% vs. 33%, P = 0.03). Although those with vitamin D deficiency had more skeletal morbidity, this was not statistically significant (73% vs 50%, P = 0.19). Reduced 25(OH) D was associated with a poor performance status (P = 0.003). There was no association between vitamin D status and stage of myeloma.

Conclusion

There is a relatively high prevalence of vitamin D deficiency in patients with myeloma in our study. This is despite a sunlight heavy, tropical climate. We report an association between vitamin D deficiency and peripheral neuropathy. Prospective interventional trials are required to further assess this.

Item ID: 66240
Item Type: Article (Research - C1)
ISSN: 1433-7339
Keywords: Multiple myeloma; Vitamin D; Peripheral neuropathy; Skeletal morbidity; Australia
Copyright Information: © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Funders: Townsville Cancer Centre
Date Deposited: 24 Feb 2021 01:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320219 Paramedicine @ 50%
42 HEALTH SCIENCES > 4202 Epidemiology > 420207 Major global burdens of disease @ 50%
SEO Codes: 20 HEALTH > 2003 Provision of health and support services > 200311 Urgent and critical care, and emergency medicine @ 50%
20 HEALTH > 2002 Evaluation of health and support services > 200202 Evaluation of health outcomes @ 50%
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