Kelly, Madeleine, Hendry, Stephanie, and Norton, Robert (2020) The utility of the syphilis enzyme immunoassay IgM in the diagnosis of congenital syphilis. Diagnostic Microbiology and Infectious Disease, 98 (3). 115152.

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Abstract

[Extract] Although the incidence of congenital syphilis in Australia is low, it is a cause of significant adverse outcomes in pregnancy and has long-term sequelae for an affected newborn. Congenital syphilis results from maternal transmission of Treponema pallidum (Peeling and Htun, 2004). The highest rates of vertical transmission are reported with untreated primary syphilis, 70–100%, decreasing to 67% for secondary syphilis (Herremans et al., 2010; Hollier et al., 2001; Porter et al., 2018). Over 60% of infants are asymptomatic at birth and present with a wide range of nonspecific sequelae including premature birth, stillbirth, hepatomegaly, skin rash, rhinitis, and osteochondritis (Cooper and Sanchez, 2018; Herremans et al., 2010).

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