The concurrent detection of chelonid alphaherpesvirus 5 and Chelonia mydas papillomavirus 1 in tumoured and non-tumoured green turtles

Mashkour, Narges, Jones, Karina, Wirth, Wytamma, Burgess, Graham, and Ariel, Ellen (2021) The concurrent detection of chelonid alphaherpesvirus 5 and Chelonia mydas papillomavirus 1 in tumoured and non-tumoured green turtles. Animals, 11 (3). 697.

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Abstract

Characterised by the growth of benign tumours, fibropapillomatosis (FP) is a debilitating disease that predominantly afflicts the endangered green turtle (Chelonia mydas). A growing body of histological and molecular evidence has consistently associated FP tumours with Chelonid alphaherpesvirus 5 (ChHV5), leading this virus to be considered the most likely aetiological agent of FP. However, a recent study which detected both ChHV5 and Chelonia mydas papillomavirus 1 (CmPV1) DNA in FP tumour tissues has challenged this hypothesis. The present study aimed to establish the wider prevalence of CmPV1 and co-occurrence with ChHV5 in marine turtles in waters adjacent to the east coast of Queensland, Australia. This comprehensive molecular survey screened a total of 353 samples from 275 foraging turtles using probe-based qPCR. Three sample categories were used in this study: Group A (FP tumours), Group B (non-tumoured skin from turtles with FP tumours) and Group C (non-tumoured skin from turtles without FP tumours). Concurrent detection of ChHV5 and CmPV1 DNA is reported for all three categories, with the highest rate of concurrent detection reported for Group A samples (43.5%). Collectively, these results pivot the way we think about FP; as an infectious disease where two separate viruses may be at play

Item ID: 65983
Item Type: Article (Research - C1)
ISSN: 2076-2615
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Copyright Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Funders: World Wildlife Fund (WWF)
Date Deposited: 09 Mar 2021 06:02
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300914 Veterinary virology @ 100%
SEO Codes: 18 ENVIRONMENTAL MANAGEMENT > 1802 Coastal and estuarine systems and management > 180204 Control of pests, diseases and exotic species in coastal and estuarine environments @ 100%
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