Identification of new flaviviruses in the Kokabera virus complex

Nisbet, Debra J., Lee, Katie J., van den Hurk, Andrew F., Johansen, Cheryl A., Kuno, Goro, Chang, Gwong-Jen J., Mackenzie, John S., Ritchie, Scott A., and Hall, Roy A. (2005) Identification of new flaviviruses in the Kokabera virus complex. Journal of General Virology, 86 (1). pp. 121-124.

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Abstract

Novel flavivirus isolates from mosquitoes collected in northern Australia were analysed by partial genomic sequencing, monoclonal antibody-binding assays and polyclonal cross-neutralization tests. Two isolates were found to be antigenically distinct from, but related to, viruses of the Kokobera virus complex, which currently contains Kokobera (KOKV) and Stratford (STRV) viruses. Nucleotide sequence comparison of two separate regions of the genome revealed that an isolate from Saibai Island in the Torres Strait in 2000 (TS5273) was related closely to KOKV and STRV, with 74–80 and 75–76 % nucleotide similarity, respectively. An isolate from mainland Cape York in 1998 (CY1014) was found to be more divergent from KOKV and STRV, with <70 % nucleotide sequence similarity to either virus. It is proposed that isolate TS5273 represents a new subtype of KOKV and that CY1014 be classified as a novel species within the Kokobera virus complex of flaviviruses, named New Mapoon virus.

Item ID: 6596
Item Type: Article (Research - C1)
ISSN: 1465-2099
Keywords: Australia; flavivirus; mosquito; virology
Date Deposited: 10 Feb 2010 02:25
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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