The loudness dependence auditory evoked potential is insensitive to acute changes in serotonergic and noradrenergic neurotransmission

Oliva, Jessica, Leung, Sumie, Croft, Rodney J., O'Neill, Barry V., O'Kane, Joanne, Stout, Julie, Phan, K. Luan, and Nathan, Pradeep J. (2010) The loudness dependence auditory evoked potential is insensitive to acute changes in serotonergic and noradrenergic neurotransmission. Human Psychopharmacology: Clinical and Experimental, 25 (5). pp. 423-427.

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Abstract

Background: The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as an electrophysiological marker for assessing serotonergic function in vivo in humans, although accumulating evidence suggests that it is insensitive to acute changes in serotonergic neurotransmission. Very little is known about the sensitivity of the LDAEP to other neurotransmitter systems including the noradrenergic system. The current study examined the effects of noradrenergic modulation as well as serotonergic modulation on the LDAEP.

Methods: The study utilised a double‐blind placebo‐controlled design in which the LDAEP in 17 healthy males and females was tested following acute administration of each of citalopram (20 mg), reboxetine (4 mg) and placebo.

Results: Neither citalopram nor reboxetine modulated the LDAEP relative to placebo treatment (p > 0.05).

Conclusion: These findings suggest that the LDAEP is insensitive to acute changes in serotonergic or noradrenergic neurotransmission and thus is a poor pharmacodynamic marker of these systems.

Item ID: 65913
Item Type: Article (Research - C1)
ISSN: 1099-1077
Keywords: LDAEP; serotonin; noradrenaline; biological marker; electrophysiology; healthy participants
Copyright Information: Copyright © 2010 John Wiley & Sons, Ltd.
Date Deposited: 03 Feb 2021 01:39
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) @ 50%
17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1702 Cognitive Science > 170205 Neurocognitive Patterns and Neural Networks @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970117 Expanding Knowledge in Psychology and Cognitive Sciences @ 100%
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