Copper and zinc isotopic excursions in the human brain affected by Alzheimer’s disease

Moynier, Frédéric, Le Borgne, Marie, Lahoud, Esther, Mahan, Brandon, Mouton-Ligier, Francois, Hugon, Jacques, and Paquet, Claire (2020) Copper and zinc isotopic excursions in the human brain affected by Alzheimer’s disease. Alzheimers & Dementia, 12 (1). e12112.

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Alzheimer’s disease (AD) is neuropathologically marked by amyloid beta (Aβ) plaques and neurofibrillary tangles. Little is known about isotopic compositions of human AD brains. Here we study this in comparison with control subjects for copper and zinc.


We use mass-spectrometry methods, developed to study extraterrestrial materials, to compare the copper and zinc isotopic composition of 10 AD and 10 con- trol brains.


Copper and zinc natural isotopic compositions of AD brains are statistically different compared to controls, and correlate with Braak stages.


The distribution of natural copper and zinc isotopes in AD is not affected by the diet, but is a consequence of Aβ plaques and tau fibril accumulation. This is well predicted by the changes of the chemical bonding environment caused by the develop- ment of Aβ lesions and accumulation of tau proteins. Future work will involve testing whether these changes affect brain functions and are propagated to body fluids.

Item ID: 65705
Item Type: Article (Research - C1)
ISSN: 1552-5279
Keywords: Alzheimer's disease; Amyloid beta; Copper; Isotopes
Copyright Information: © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Funders: Centre National de la Recherche Scientifique (CNRS), Université Sorbonne Paris Cité (USPC), Institut de Physique du Globe de Paris (IDGP), Région Ile-de-France (RIDF)
Projects and Grants: CNRS grant MAMI, IDGP multi-disciplinary program PARI, RIDF SESAME Grant number 12015908
Date Deposited: 16 Feb 2021 23:21
FoR Codes: 34 CHEMICAL SCIENCES > 3402 Inorganic chemistry > 340201 Bioinorganic chemistry @ 33%
34 CHEMICAL SCIENCES > 3402 Inorganic chemistry > 340211 Transition metal chemistry @ 34%
46 INFORMATION AND COMPUTING SCIENCES > 4606 Distributed computing and systems software > 460606 Energy-efficient computing @ 33%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920112 Neurodegenerative Disorders Related to Ageing @ 100%
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