The role of DNA damage and repair in liver cancer

Gillman, Rhys, Lopes Floro, Kylie, Wankell, Miriam, and Hebbard, Lionel (2020) The role of DNA damage and repair in liver cancer. Biochimica et Biophysica Acta Reviews on Cancer, 1875 (1). 188493.

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Abstract

Hepatocellular carcinoma is rapidly becoming a major cause of global mortality due to the ever-increasing prevalence of obesity. DNA damage is known to play an important role in cancer initiation, however DNA repair systems are also vital for the survival of cancer cells. Given the function of the liver and its exposure to the gut, it is likely that DNA damage and repair would be of particular importance in hepatocellular carcinoma. However, many contemporary reports have neglected the role of individual pathways of DNA damage and repair in their hypotheses. This review, therefore, aims to provide a concise overview for researchers in the field of liver cancer to understand the pathways of DNA damage and repair and their individual roles in hepatocellular carcinoma.

Item ID: 65483
Item Type: Article (Research - C1)
ISSN: 0304-419X
Keywords: DNA repair, Hepatocellular carcinoma, Polymorphism, Synthetic lethality
Copyright Information: Copyright © 2021 Elsevier B.V. All rights reserved.
Funders: James Cook University (JCU), Cancer Council Queensland (QCC), Townsville University Hospital Study, Education and Research Trust Account (SERTA), Royal Australian and New Zealand College of Radiologists (RANZCR)
Projects and Grants: JCU Postgraduate Research Scholarship, QCC APP1123436, SERTA research grant 2019_11, 2018/RANZCR\001
Date Deposited: 27 Jan 2021 03:46
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321111 Solid tumours @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321110 Radiation therapy @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 100%
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