Nijs, Jo, De Meirleir, Kenny, Coomans, Danny, De Becker, Pascale, and Nicolson, Garth L. (2003) Deregulation of the 2,5A Synthetase Rnase L Antiviral pathway by Mycoplasma spp. in subsets of chronic fatigue syndrome. Journal of Chronic Fatigue Syndrome, 11 (2). pp. 37-50.

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Abstract

The deregulation of the 2,5A synthetase RNase L antiviral pathway and the prevalence of Mycoplasma spp. in subsets of Chronic Fatigue Syndrome (CFS) have been separately reported in the scientific literature. We hypothesised that a co-morbid pathophysiological mechanism involving infection by Mycoplasma spp. and the deregulation of the 2,5A synthetase/RNase L antiviral pathway may exist in CFS. Therefore, 186 consecutive CFS patients were enrolled. Mycoplasma detection was performed using forensic polymerase chain reaction. For RNase L determination, a radioactive probe was used to label 2,5A binding proteins in unfractionated peripheral blood mononuclear cell extracts. Myco-plasma-infected CFS patients presented with significantly elevated RNase L-ratio, compared to non-infected age- and sex-matched patients (p = 0.016). These results suggest that mycoplasma infections may cause deregulation of the 2,5A synthetase RNase L antiviral pathway in patients with CFS

Item ID:	6543
Item Type:	Article (Research - C1)
ISSN:	1057-3321
Keywords:	2,5A synthetase Rnase L antiviral pathway; chronic fatigue syndrome; mycoplasma
Related URLs:	Publisher
Date Deposited:	05 Apr 2010 23:52
FoR Codes:	01 MATHEMATICAL SCIENCES > 0104 Statistics > 010401 Applied Statistics @ 100%
SEO Codes:	92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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