Professionally delivered local antimicrobials in the treatment of patients with periodontitis— a narrative review

Sholapurkar, Amar, Sharma, Dileep, Glass, Beverley, Miller, Catherine, Nimmo, Alan, and Jennings, Ernest (2021) Professionally delivered local antimicrobials in the treatment of patients with periodontitis— a narrative review. Dentistry Journal, 9 (1). 2.

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This review sheds light on the recent published scientific evidence relating to the use of professionally delivered local antimicrobial agents (L's). The review also analyses drug delivery systems available to date and provides an update on the latest scientific evidence about the benefits, limitations, and clinical results obtained by use of local drugs in the treatment of periodontal disease. The search strategy revealed randomized controlled trials (RCTs) that compared the efficacy of adjunctive LA's to mechanical therapy alone. Based on the available evidence gathered from this review, we can infer that the use of local antimicrobial agents in conjunction to scaling and root debridement (SRD) delivers significant benefits in periodontal therapy and it is a useful aid, avoiding many of the side effects that systemic antibiotic therapy may involve. Local drug delivery (LDD) is an efficient and effective means of delivering drugs based on the evidence presented in the review. The authors of this review would suggest the use of local antimicrobials in cases of localized periodontitis or individual areas that do not respond to the usual mechanical therapy alone. This review summarizes the current use of local drug delivery in periodontal management ensuring that the general practitioners are able to choose an appropriate local antimicrobia.

Item ID: 65403
Item Type: Article (Research - C1)
ISSN: 2304-6767
Keywords: local antimicrobials; local antibiotics; topical oral antibiotic; local drug delivery; periodontitis; periodontal therapy; periodontal treatment; scaling and root planning; scaling and root debridement
Copyright Information: Copyright:© 2020by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and con-ditions of the Creative Commons Attribution (CC BY) license (
Date Deposited: 03 Jan 2021 23:28
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320310 Periodontics @ 75%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320303 Dental therapeutics, pharmacology and toxicology @ 25%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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