Does the addition of zinc oxide nanoparticles improve the antibacterial properties of direct dental composite resins? A systematic review

Arun, Divya, Adikari Mudiyanselage, Dulanja, Gulam Mohamed, Rumana, Liddell, Michael, Monsur Hassan, Nur Mohammad, and Sharma, Dileep (2020) Does the addition of zinc oxide nanoparticles improve the antibacterial properties of direct dental composite resins? A systematic review. Materials, 14 (1). 40.

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A promising approach to improve the poor antibacterial properties of dental composite resins has been the addition of metal oxide nanoparticles into the resin matrix. This systematic review aimed to determine whether the addition of zinc oxide nanoparticles (ZnO-NPs) improves the antibacterial properties of direct dental composite resins. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered with the PROSPERO database: CRD42019131383. A systematic literature search was conducted using the following databases: Medline (Ovid), the Cochrane Library, SCOPUS, CINAHL, Web of Science, Trove, Google Scholar, World Cat, and OpenGrey. The initial search retrieved 3178 results, which were then screened against inclusion and exclusion criteria, resulting in a total of four studies that were eligible for qualitative synthesis within this review. All the included studies were in vitro non-randomized post-test design experimental studies. A lack of congruity in the results obtained from these studies that used different tests to evaluate antibacterial activity was evident. Although some studies demonstrated a significant improvement of antibacterial properties in composites containing at least 1% ZnO-NPs (wt %), they are unlikely to present any clear clinical advantage due to the short lifetime of observed antibacterial properties.

Item ID: 65402
Item Type: Article (Research - C1)
ISSN: 1996-1944
Keywords: antibacterial agents; composite resin; zinc oxide; nanoparticles; zinc oxide nanoparticles; dentistry; dental materials; systematic review
Copyright Information: Copyright:© 2020 by the authors. Li-censee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)license (
Date Deposited: 10 Feb 2021 01:11
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320302 Dental materials and equipment @ 80%
40 ENGINEERING > 4016 Materials engineering > 401602 Composite and hybrid materials @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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