Impact of hookworms and their secreted proteins on the microbiota and subsequent development of type 2 diabetes in mice
Agha, Zainab Khudhair (2020) Impact of hookworms and their secreted proteins on the microbiota and subsequent development of type 2 diabetes in mice. PhD thesis, James Cook University.
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DOI: 10.25903/2ngn-wv51
View at Publisher Website: https://doi.org/10.25903/2ngn-wv51
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Abstract
Zainab Khudhair Agha examined the potential of Nippostrongylus brasiliensis infections and their excretory/secretory (ES) proteins as therapeutics in mouse models of T2D. Agha found that infection with N. brasiliensis or their ES protected against T2D. This reveals novel mechanisms by which gastrointestinal nematodes and their ES proteins can be harnessed as a source of next generation therapeutics for inflammatory and metabolic diseases.
| Item ID: | 65327 |
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| Item Type: | Thesis (PhD) |
| Keywords: | helminths, hookworms, Nippostrongylus brasiliensis, secreted proteins, excretory/secretory (ES) proteins, type 2 diabetes (T2D), inflammatory immune responses, gut microbiota, mouse models, therapeutics |
| Copyright Information: | © 2020 Zainab Khudhair Agha. |
| Date Deposited: | 17 Dec 2020 02:48 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100% |
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