A short commentary on potential role of the IFN-γ/mini-TrpRS signaling axis in abdominal aortic aneurysm

Moran, Corey S., Velu, Ramesh B., Vangaveti, Venkat, Malabu, Usman H., and Biros, Erik (2020) A short commentary on potential role of the IFN-γ/mini-TrpRS signaling axis in abdominal aortic aneurysm. Archives of Clinical and Biomedical Research, 4. 4. pp. 361-366.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (689kB) | Preview
View at Publisher Website: https://doi.org/10.26502/acbr.50170109
 
21


Abstract

Aneurysms demonstrate vascular smooth muscle cells (VSMC) phenotypic modulation characterized by the prevailing of synthetic over contractile properties. We have shown previously the ability of interferon-gamma (IFN-γ) to switch VSMC from contractile to synthetic phenotype via upregulating the truncated form of tryptophanyl-tRNA synthetase (mini-TrpRS) in vitro. Here we discuss a possible role of the IFN-γ/mini-TrpRS signalling axis in the pathology of human abdominal aortic aneurysm (AAA).

Item ID: 65288
Item Type: Article (Commentary)
ISSN: 2572-9292
Keywords: Mini tryptophanyl-tRNA synthetase; Interferon-gamma; Abdominal aortic aneurysm
Copyright Information: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license 4.0.
Date Deposited: 18 Jan 2021 23:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
Downloads: Total: 21
Last 12 Months: 9
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page