Moran, Corey S., Velu, Ramesh B., Vangaveti, Venkat, Malabu, Usman H., and Biros, Erik (2020) A short commentary on potential role of the IFN-γ/mini-TrpRS signaling axis in abdominal aortic aneurysm. Archives of Clinical and Biomedical Research, 4. 4. pp. 361-366.

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Abstract

Aneurysms demonstrate vascular smooth muscle cells (VSMC) phenotypic modulation characterized by the prevailing of synthetic over contractile properties. We have shown previously the ability of interferon-gamma (IFN-γ) to switch VSMC from contractile to synthetic phenotype via upregulating the truncated form of tryptophanyl-tRNA synthetase (mini-TrpRS) in vitro. Here we discuss a possible role of the IFN-γ/mini-TrpRS signalling axis in the pathology of human abdominal aortic aneurysm (AAA).

Item ID:	65288
Item Type:	Article (Commentary)
ISSN:	2572-9292
Keywords:	Mini tryptophanyl-tRNA synthetase; Interferon-gamma; Abdominal aortic aneurysm
Copyright Information:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license 4.0.
Date Deposited:	18 Jan 2021 23:17
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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