Blockade of mini-TrpRS for treatment of diabetic foot syndrome

Biros, Erik, Vangaveti, Venkat, Moran, Corey S., and Malabu, Usman H. (2020) Blockade of mini-TrpRS for treatment of diabetic foot syndrome. Clinical Research and Trials, 6.

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Abstract

Diabetic foot syndrome demonstrates wound chronicity due to impaired tissue perfusion in lower limbs. Previous studies showed interferon-gamma (IFN-γ), a central inflammatory mediator in diabetic foot syndrome, to induce the truncated form of tryptophanyl-tRNA synthetase (mini-TrpRS) that has strong angiostatic properties. Recently we reported that mini-TrpRS signalling could be blocked in the presence of IFN-γ with D-tryptophan in vitro. Here we discuss the IFN-γ/mini-TrpRS axis in the pathology of diabetic foot syndrome and emerging therapeutic options.

Item ID: 65287
Item Type: Article (Other)
ISSN: 2059-0377
Keywords: mini tryptophanyl-tRNA synthetase, interferon-gamma, diabetic foot syndrome
Copyright Information: © 2020 Biros E (2020) This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funders: College of Medicine and Dentistry, James Cook University
Date Deposited: 11 Feb 2021 02:29
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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