Blockade of mini-TrpRS for treatment of diabetic foot syndrome
Biros, Erik, Vangaveti, Venkat, Moran, Corey S., and Malabu, Usman H. (2020) Blockade of mini-TrpRS for treatment of diabetic foot syndrome. Clinical Research and Trials, 6.
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Abstract
Diabetic foot syndrome demonstrates wound chronicity due to impaired tissue perfusion in lower limbs. Previous studies showed interferon-gamma (IFN-γ), a central inflammatory mediator in diabetic foot syndrome, to induce the truncated form of tryptophanyl-tRNA synthetase (mini-TrpRS) that has strong angiostatic properties. Recently we reported that mini-TrpRS signalling could be blocked in the presence of IFN-γ with D-tryptophan in vitro. Here we discuss the IFN-γ/mini-TrpRS axis in the pathology of diabetic foot syndrome and emerging therapeutic options.
Item ID: | 65287 |
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Item Type: | Article (Other) |
ISSN: | 2059-0377 |
Keywords: | mini tryptophanyl-tRNA synthetase, interferon-gamma, diabetic foot syndrome |
Copyright Information: | © 2020 Biros E (2020) This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Funders: | College of Medicine and Dentistry, James Cook University |
Date Deposited: | 11 Feb 2021 02:29 |
FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100% |
SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100% |
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