Gut microbiota composition in obese and non-obese adult relatives from the highlands of Papua New Guinea

Jonduo, Marinjho E., Wawae, Lorry, Masiria, Geraldine, Suda, Wataru, Hattori, Masahira, Takayasu, Lena, Abdad, Mohammad Y., Greenhill, Andrew R., Horwood, Paul F., Pomat, William, and Umezaki, Masahiro (2020) Gut microbiota composition in obese and non-obese adult relatives from the highlands of Papua New Guinea. FEMS Microbiology Letters, 367 (19). fnaa161.

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Obesity is a condition that results from an imbalance between energy intake and expenditure. Recently, obesity has been linked to differences in the composition of gut microbiota. To examine this association in Papua New Guinea (PNG) highlanders, fecal samples were collected from 18 adults; nine obese participants were paired with their non-obese relative. Amplification of the 16S rRNA gene targeting the V1–V2 region was performed on DNA extracts for each participant, with high-quality sequences selected and used for operational taxonomic unit clustering. The data showed Firmicutes and Bacteroidetes were the two dominant phyla, while at genus level Prevotella was the most dominant genus in all of the samples. Nonetheless, statistical evaluation of potential association between nutritional status and bacterial abundance at both phyla and genus levels showed no significant difference. Further studies, ideally in both rural and urban areas, are needed to evaluate the role of the gut microbiome in the occurrence of obesity in PNG and other resource-limited settings.

Item ID: 64920
Item Type: Article (Research - C1)
ISSN: 1574-6968
Keywords: gut microbiota, Papua New Guinea, obese, non-obese, Prevotella
Copyright Information: © The Author(s) 2020. Published by Oxford University Press on behalf of FEMS.
Funders: Japan Society for the Promotion of Science (JSPS), Takeda Science Foundation, TANITA Healthy Weight Community Trust
Projects and Grants: JSPS KAKENHI Grant number 15H04430
Date Deposited: 03 Nov 2020 01:52
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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