Management of peri-implantitis lesions without the use of systemic antibiotics: a systematic review

Khan, Ahsen, Goyal, Ankit, Currell, Scott D., and Sharma, Dileep (2020) Management of peri-implantitis lesions without the use of systemic antibiotics: a systematic review. Dentistry Journal, 8 (3). 106.

PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (716kB) | Preview
View at Publisher Website:


Background: This systematic review aims to assess the current evidence on the efficacy of surgical and non-surgical debridement techniques in the treatment of peri-implantitis lesions without the use of any antimicrobials. Method: Five electronic databases (MEDLINE, Pubmed, Scopus, CINAHL and Cochrane) were used, alongside hand searches, to find relevant articles. Full-text articles that were randomised controlled trials, published in the English language from 2011 onwards without pre-operative, peri-operative and post-operative antibiotic usage were included. The study was conducted according to the latest Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-P protocols, the latest Cochrane Risk of Bias tool and each investigated intervention was evaluated using the grading of recommendation, assessment, development and evaluation (GRADE) system. Results: The search yielded 2718 results. After initial screening, 38 full-text articles were assessed for eligibility. From these, 11 studies satisfied all inclusion criteria. These 11 articles described six non-surgical and five surgical debridement therapies. Most articles were classified as having either a high risk of bias or presenting with some concerns. Small sample sizes, in combination with this risk of bias, meant that all interventions were adjudged to be of either low or very low quality of evidence. Conclusion: While all investigated modalities displayed some sort of efficacy, this review suggests that a surgical approach may be best suited to treating peri-implantitis lesions in the absence of antibiotic therapy. Despite this weak indication, further research is required in this field.

Item ID: 64357
Item Type: Article (Research - C1)
ISSN: 2304-6767
Keywords: peri-implantitis; decontamination; debridement; nonsurgical therapy
Copyright Information: ©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (
Funders: James Cook University
Projects and Grants: College of Medicine and Dentistry Honours program fund
Date Deposited: 15 Sep 2020 19:01
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320306 Oral implantology @ 65%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320310 Periodontics @ 35%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
Downloads: Total: 646
Last 12 Months: 52
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page