A systematic review on the health outcomes associated with non-endocarditis manifestations of chronic Q fever

Manchal, Naveen, Adegboye, Oyelola A., and Eisen, Damon P. (2020) A systematic review on the health outcomes associated with non-endocarditis manifestations of chronic Q fever. European Journal of Clinical Microbiology & Infectious Diseases, 39. pp. 2225-2233.

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The aim of this study was to systematically review the non-endocarditis manifestations of chronic Q fever and understand the significance of non-specific symptoms like pain and fatigue in chronic endovascular, osteomyelitis and abscess due to chronic Q fever. We performed a systematic review using Pub Med (the National Library of Medicine (NLM)) and Scopus databases. All studies in English on chronic Q fever that listed clinical manifestations other than infective endocarditis (IE) and chronic fatigue syndrome (CFS). Meta-analysis was carried out to investigate the effects of patient’s health outcomes (pain, fatigue, the need for surgery and mortality) on vascular infections, osteomyelitis and abscess. Among cases not presenting as IE or CFS, vascular infections and osteomyelitis were the most common chronic Q fever disease manifestations. There were distinct regional patterns of disease. Compared with infective endocarditis, these are significantly associated with increased risk of pain: osteomyelitis (relative risk (RR) = 4.13, 95% confidence interval (CI) 3.36–5.07), abscess (RR = 3.59, 95% CI 3.28–3.93) and vascular infection (RR = 2.46, 95% CI 1.99–3.03). The strongest significant association was observed between osteomyelitis and pain. There was no significant association between fatigue and these manifestations. Clinicians have to be aware of uncommon manifestations of chronic Q fever as they present with non-specific symptoms and are significantly associated with increased risk of morbidity and mortality. The findings emphasise the need to investigate patients with positive chronic Q fever serology presenting with acute or chronic pain for possible underlying complications.

Item ID: 64223
Item Type: Article (Research - C1)
ISSN: 1435-4373
Keywords: Chronic Q fever; Coxiella burnetii infection; Infective endocarditis
Copyright Information: © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Date Deposited: 02 Sep 2020 00:34
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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