The protective potential of Fc‐mediated antibody functions against influenza virus and other viral pathogens

Vanderven, Hillary A, and Kent, Stephen J (2020) The protective potential of Fc‐mediated antibody functions against influenza virus and other viral pathogens. Immunology and Cell Biology, 98. pp. 253-263.

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Abstract

In recent years, there has been a renewed interest in utilizing antibody fragment crystallizable (Fc) functions to prevent and control viral infections. The protective and therapeutic potential of Fc‐mediated antibody functions have been assessed for some clinically important human viruses, including HIV, hemorrhagic fever viruses and influenza virus. There is mounting evidence that influenza‐specific antibodies with Fc‐mediated functions, such as antibody‐dependent cellular cytotoxicity and antibody‐dependent phagocytosis, can aid in the clearance of influenza virus infection. Recent influenza challenge studies and intravenous immunoglobulin G therapy studies in humans suggest a protective role for Fc effector functions in vivo. Broadly reactive influenza antibodies with Fc‐mediated functions are prevalent in the human population and could inform the development of a universally protective influenza vaccine or therapy. In this review, we explore the utility of antibodies with Fc‐mediated effector functions against viral infections with a focus on influenza virus.

Item ID: 64202
Item Type: Article (Research - C1)
ISSN: 1440-1711
Keywords: antibodies, antibody-dependent cellular cytotoxicity, antibody-dependent phagocytosis, Fc receptors, influenza virus, natural killer cells
Copyright Information: © 2020 Australian and New Zealand Society for Immunology Inc.
Funders: James Cook University
Projects and Grants: National Health and Medical Research Council (NHMRC) 1052979
Date Deposited: 30 Aug 2020 14:29
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320705 Medical virology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
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