IL-17A moonlighting in lung type 2 immunity

Ruscher, Roland, and Giacomin, Paul (2020) IL-17A moonlighting in lung type 2 immunity. Mucosal Immunology. (In Press)

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Abstract

Both Type 2 inflammation and the cytokine IL-17A are implicated in allergic asthma, yet how these distinct immune responses are interlinked in the lung remains poorly understood. Utilizing helminth infection models in mice to induce pulmonary Type 2 immunity, Ajendra et al. reveal a molecular switch, where IL-17A initially acts to promote the establishment of the Type 2 response to infection by inhibiting IFNγ production, but at later stages IL- 17A acts to reduce Type 2 responses, protecting the lung tissue from detrimental chronic inflammation. Interestingly, the multitasking function of IL-17A in regulating lung Type 2 inflammation was even observed when mice were infected with a different helminth species that resides entirely in the gastrointestinal tract. These novel findings advance our understanding of how IL-17A plays multiple “moonlighting” functions in regulating pulmonary Type 2 inflammation, which has implications for the etiology of severe asthma.

Item ID: 64044
Item Type: Article (Research - C1)
ISSN: 1935-3456
Copyright Information: © Society for Mucosal Immunology 2020
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: GNT1178968
Date Deposited: 31 Aug 2020 18:50
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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