A novel function for HEG1 in promoting metastasis in hepatocellular carcinoma

Dewdney, Brittany, and Hebbard, Lionel (2019) A novel function for HEG1 in promoting metastasis in hepatocellular carcinoma. Clinical Science, 133 (19). pp. 2019-2022.

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Abstract

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related deaths around the globe. For patients receiving liver tumour resection, the risk of reoccurrence and metastasis is high. Cancer metastasis can occur as a consequence of a physical change known as epithelial to mesenchymal transition (EMT). In this instance, cancer cells acquire migratory and invasive characteristics that allow the cells to move into adjacent tissue or enter the bloodstream to reach a secondary site, where they begin to form a new tumour. Targetting proteins involved in the signalling pathways that induce the mesenchymal phenotype has been an ongoing field of research. A recently published study has described a novel role for the heart development protein with EGF-like domains (HEG1) in promoting EMT. This research provides new insights into the biological function of this protein in HCC. Furthermore, the research indicates a new target for future prognostic and therapeutic research in HCC.

Item ID: 63879
Item Type: Article (Commentary)
ISSN: 1470-8736
Keywords: epithelial-to-mesenchymal transition, hepatocellular carcinoma, metastasis
Copyright Information: © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Funders: Cancer Council Queensland (CCQ)
Projects and Grants: CCQ grant number APP1123436
Date Deposited: 28 Jul 2020 01:45
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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