Immune reconstitution inflammatory syndrome following Cryptococcal neoformans infection in an immunocompetent host: a case report and review of the literature
Kathiresu, Raguharan, Zinat, Syeda Nabila, and Fernando, Malindu (2020) Immune reconstitution inflammatory syndrome following Cryptococcal neoformans infection in an immunocompetent host: a case report and review of the literature. IDCases, 19. e00699.
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Abstract
We present a case of Cryptococcus neoformans in an immunocompetent middle-aged woman with a disseminated manifestation of pulmonary cryptoccoma and cryptococcal meningitis resulting in bilateral blindness. The presentation was complicated by delayed diagnosis resulting in optic neuritis and an infected percutaneous lumbar drainage with methicillin resistant staphylococcus aureus (MRSA) and a paradoxical reaction of suspected immune reconstitution inflammatory syndrome (IRIS). We discuss the pathogen, the clinical manifestations and diagnostic approach (through laboratory and radiology findings), differential diagnosis, treatment, and proposed pathogenesis of IRIS and C. neoformans in an immunocompetent patient.
| Item ID: | 63847 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 2214-2509 |
| Keywords: | Cryptococcus, C. neoformans, Atypical presentations |
| Copyright Information: | © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Date Deposited: | 22 Jul 2020 07:37 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 100% |
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