Relationship between disease specific quality of life measures, physical performance, and activity in people with intermittent claudication caused by peripheral artery disease

Golledge, Jonathan, Leicht, Anthony S., Yip, Lisan, Rowbotham, Sophie E., Pinchbeck, Jenna, Jenkins, Jason S., Clapperton, Roslyn, Dally-Watkins, Matthew, Fiatarone Singh, Maria A., Mavros, Yorgi, Noble, Yian, Haghighi, Marjan M., Hollings, Matthew, Parmenter, Belinda J., and Burton, Nicola W. (2020) Relationship between disease specific quality of life measures, physical performance, and activity in people with intermittent claudication caused by peripheral artery disease. European Journal of Vascular and Endovascular Surgery, 59 (6). pp. 957-964.

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Abstract

Objective

The aims of this study were firstly to assess the correlation between disease specific measures of quality of life (QOL) and physical performance and activity, and secondly to identify demographic, clinical, functional, and physical activity measures independently associated with QOL in people with intermittent claudication.

Methods

This was a cross sectional observational study of 198 people with intermittent claudication caused by peripheral artery disease who were recruited prospectively. QOL was assessed with the intermittent claudication questionnaire (ICQ) and the eight-theme peripheral artery disease quality of life questionnaire. Physical performance was assessed with the six minute walk test (6MWT) and short physical performance battery (SPPB), and an accelerometer was used to measure seven day step count. The associations between QOL scores and 6MWT distance, SPPB scores and seven day step count were examined using Spearman Rho's (ρ) correlation and multivariable linear regression.

Results

ICQ scores were significantly correlated with 6MWT distance (ρ = 0.472, p < .001), all four SPPB scores (balance ρ = 0.207, p = .003; gait speed ρ = 0.303, p < .001; chair stand ρ = 0.167, p = .018; total ρ = 0.265, p < .001), and seven day step count (ρ = 0.254, p < .001). PADQOL social relationships and interactions (ρ = 0.343, p < .001) and symptoms and limitations in physical functioning (ρ = 0.355, p < .001) themes were correlated with 6MWT distance. The 6MWT distance was independently positively associated with ICQ and both PADQOL theme scores (ICQ: B 0.069, p < .001; PADQOL social relationships and interactions: B 0.077, p < .001; PADQOL symptoms and limitations in physical functioning: B 0.069, p < .001).

Conclusion

Longer 6MWT distance independently predicted better physical and social aspects of QOL in people with intermittent claudication supporting its value as an outcome measure.

Item ID: 63771
Item Type: Article (Research - C1)
ISSN: 1532-2165
Keywords: Peripheral artery disease; Physical activity; Physical performance; Quality of life
Copyright Information: Crown Copyright © 2020 Published by Elsevier B.V. on behalf of European Society for Vascular Surgery. All rights reserved.
Funders: National Health and Medical Research Council (NHMRC), Townsville Hospital and Health Service (THHS), James Cook University (JCU), Queensland Government (QG)
Projects and Grants: NHMRC 1063476, THHS Study, Education and Research Trust Fund, NHMRC 1117061, QG Senior Clinical Research Fellowship
Date Deposited: 08 Jul 2020 07:32
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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