The application of self-assembled nanostructures in peptide-based subunit vaccine development

Zhao, Guangzu, Chandrudu, Saranya, Skwarczynski, Mariusz, and Toth, Istvan (2017) The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal, 93. pp. 670-681.

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Abstract

Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.

Item ID: 63629
Item Type: Article (Research - C1)
ISSN: 1873-1945
Keywords: Conjugation, Lipopeptide, Nanofiber, Nanoparticle, Polymer, Self-assembly, Vaccine
Copyright Information: © 2017 Elsevier Ltd.
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC Program Grant 496600
Date Deposited: 11 Aug 2020 23:43
FoR Codes: 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310113 Synthetic biology @ 33%
31 BIOLOGICAL SCIENCES > 3106 Industrial biotechnology > 310607 Nanobiotechnology @ 33%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 34%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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