The application of self-assembled nanostructures in peptide-based subunit vaccine development
Zhao, Guangzu, Chandrudu, Saranya, Skwarczynski, Mariusz, and Toth, Istvan (2017) The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal, 93. pp. 670-681.
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Abstract
Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.
| Item ID: | 63629 |
|---|---|
| Item Type: | Article (Research - C1) |
| ISSN: | 1873-1945 |
| Keywords: | Conjugation, Lipopeptide, Nanofiber, Nanoparticle, Polymer, Self-assembly, Vaccine |
| Copyright Information: | © 2017 Elsevier Ltd. |
| Funders: | National Health and Medical Research Council of Australia (NHMRC) |
| Projects and Grants: | NHMRC Program Grant 496600 |
| Date Deposited: | 11 Aug 2020 23:43 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310113 Synthetic biology @ 33% 31 BIOLOGICAL SCIENCES > 3106 Industrial biotechnology > 310607 Nanobiotechnology @ 33% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 34% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100% |
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