Ketogenic therapy in neurodegenerative and psychiatric disorders: from mice to men

Kraeuter, Ann-Katrin, Phillips, Riana, and Sarnyai, Zoltán (2020) Ketogenic therapy in neurodegenerative and psychiatric disorders: from mice to men. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 101. 109913.

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Ketogenic diet is a low carbohydrate and high fat diet that has been used for over 100 years in the management of childhood refractory epilepsy. More recently, ketogenic diet has been investigated for a number of metabolic, neurodegenerative and neurodevelopmental disorders. In this comprehensive review, we critically examine the potential therapeutic benefits of ketogenic diet and ketogenic agents on neurodegenerative and psychiatric disorders in humans and translationally valid animal models. The preclinical literature provides strong support for the efficacy of ketogenic diet in a variety of diverse animal models of neuropsychiatric disorders. However, the evidence from clinical studies, while encouraging, particularly in Alzheimer’s disease, psychotic and autism spectrum disorders, is limited to case studies and small pilot trials. Firm conclusion on the efficacy of ketogenic diet in psychiatric disorders cannot be drawn due to the lack of randomised, controlled clinical trials. The potential mechanisms of action of ketogenic therapy in these disorders with diverse pathophysiology may include energy metabolism, oxidative stress and immune/inflammatory processes. In conclusion, while ketogenic diet and ketogenic substances hold promise pre-clinically in a variety of neurodegenerative and psychiatric disorders, further studies, particularly randomised controlled clinical trials, are warranted to better understand their clinical efficacy and potential side effects.

Item ID: 63600
Item Type: Article (Research - C1)
ISSN: 0278-5846
Keywords: neurodegenerative disorders; psychiatric disorders; inflammation; oxidative stress; glucose metabolism
Copyright Information: © 2020 Elsevier Inc. All rights reserved.
Funders: James Cook University
Projects and Grants: JCU Postgraduate Research Scholarship, JCU Higher Degree Research Enhancement Scheme
Date Deposited: 06 Aug 2020 06:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320903 Central nervous system @ 70%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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