Potential link of single nucleotide polymorphisms (SNPs) to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa

van Schalkwyk, Antoinette, Pravesh, Kara, Ebersohn, Karen, Mather, Arshad, Annandale, Cornelius Henry, Venter, Estelle Hildegard, and Wallace, David Brian (2020) Potential link of single nucleotide polymorphisms (SNPs) to virulence of vaccine‐associated field strains of lumpy skin disease virus in South Africa. Transboundary and Emerging Diseases, 67 (6). pp. 2946-2960.

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View at Publisher Website: https://doi.org/10.1111/tbed.13670
 
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Abstract

South Africa is endemic for lumpy skin disease and is therefore reliant on various live attenuated vaccines for the control and prevention of the disease. In recent years, wide‐spread outbreaks of vaccine‐like strains of lumpy skin disease virus (LSDV) were reported internationally, leading to an increase in the generation of full genome sequences from field isolates. In this study, the complete genomes of six LSDVs submitted during active outbreaks in the 1990’s in South Africa were generated. Based on phylogenetic analysis, the six viruses clustered with vaccine strains in LSDV Subgroup 1.1 and are subsequently referred to as vaccine‐associated. The genetic differences between the phenotypically distinct vaccine and vaccine‐associated strains were 67 single nucleotides polymorphisms (SNPs). This study characterised the location and possible importance of each of these SNPs in their role during virulence and host specificity.

Item ID: 63507
Item Type: Article (Research - C1)
ISSN: 1865-1682
Keywords: emerging diseases, pathogenesis, sequences, vaccine, virus
Copyright Information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2020 Agricultural Research Council. © 2020 Blackwell Verlag GmbH.
Funders: Gauteng Department of Agriculture and Rural Development, Horizon 2020 (H2)
Projects and Grants: H2 Framework Programme, Grant/Award Number: 773701
Date Deposited: 15 Dec 2020 21:28
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300914 Veterinary virology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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