Triple therapeutic effects of Ketamine in prehospital settings: systematic review

Wongtongkam, Nualnong, and Adams, Margaret E. (2020) Triple therapeutic effects of Ketamine in prehospital settings: systematic review. Current Emergency and Hospital Reports, 8. pp. 122-132.

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Purpose of Review: Ketamine is a unique drug that, remarkably, provides three clinical benefits of analgesia, assisting intubation and sedation. It has minimal adverse events and may have major advantages for trauma patients and those with violent behaviours in prehospital environments. Twenty-one full-text articles were retrieved from 1119 journal abstracts in the databases PubMed,ScienceDirect and Taylor & Francis Group, and the Quality Assessment Tool for Quantitative Studies from the Effective Public Health Practice Project was used to assess their quality.

Recent Findings: Findings clearly demonstrated significant pain reduction with rapid onset for trauma patients, and adequate prehospital sedation in profoundly agitated patients was achieved after administration of ketamine, similar to other drugs.Nevertheless, there was inconclusive evidence about the efficacy of ketamine as an induction agent for endotracheal intubation because of the limited number of journal articles, their weak quality and high complication rates.

Summary: Although this review could not demonstrate triple benefits of ketamine use in the prehospital setting, it showed that ketamine has the potential to provide a range of clinical benefits in situations that paramedics deal with on daily basis.

Item ID: 63212
Item Type: Article (Research - C1)
ISSN: 2167-4884
Keywords: systematic review; ketamine; triple effects.
Date Deposited: 21 Jul 2020 23:14
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320219 Paramedicine @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321402 Clinical pharmacology and therapeutics @ 30%
42 HEALTH SCIENCES > 4203 Health services and systems > 420305 Health and community services @ 20%
SEO Codes: 92 HEALTH > 9202 Health and Support Services > 920204 Evaluation of Health Outcomes @ 40%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 30%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 30%
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