Pathogenesis of varicose veins

Golledge, J., and Quigley, F.G. (2003) Pathogenesis of varicose veins. European Journal of Vascular and Endovascular Surgery, 25 (4). pp. 319-324.

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Background: varicose veins are present in up to 40% of the population. They may be associated with considerable morbidity. Around 70% of patients with chronic venous insufficiency have evidence of superficial venous incompetence on duplex imaging.

Methods: in this publication we review the evidence available regarding the pathogenesis of varicose veins. Results: a number of theories have been suggested. The present data suggests that abnormalities in the venous endothelium and smooth muscle cells result in vein wall dilatation with secondary valvular incompetence. However, there is also evidence to support acquired venous valve failure. Congenital venous valve abnormalities have not been well studied.

Conclusion: further work is required on this relatively neglected topic. The use of improved imaging such as highresolution ultrasound is likely to significantly improve our understanding of venous valve function and pathology.

Item ID: 6316
Item Type: Article (Research - C1)
ISSN: 1532-2165
Keywords: pathogenesis; varicose veins
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Date Deposited: 10 Feb 2010 03:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 100%
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