Promoting independence in Lewy body dementia through exercise (PRIDE) study: protocol for a pilot study
Inskip, Michael, Mavros, Yorgi, Sachdev, Perminder S., and Fiatarone Singh, Maria A. (2019) Promoting independence in Lewy body dementia through exercise (PRIDE) study: protocol for a pilot study. Contemporary Clinical Trials Communications, 16. 100466.
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Abstract
Background: Lewy Body dementia (LBD) is the second most prevalent neurodegenerative dementia. This form of dementia is notable for an aggressive disease course consisting of a combination of cognitive, Parkinsonian, affective, and physiological symptoms that significantly increase morbidity and mortality, and decrease life expectancy in this population compared to more common dementias. Additionally, those diagnosed with LBD are often excluded from trials evaluating exercise in similar diseases such as Alzheimer's disease or Parkinson's disease due to the complexity and concurrency of motor and cognitive symptoms. Consequently, there is scarce research evaluating the effect of exercise on individuals with LBD.
Methods: The PRomoting Independence in Lewy Body Dementia through Exercise (PRIDE) trial is a novel non-randomised, crossover pilot study consisting of an 8-week wait-list usual care period, followed by an 8-week exercise intervention targeting progressive resistance and balance training. The trial aim is to evaluate the effect of exercise on the primary outcome of functional independence and secondary outcomes including cognitive, physical, psychosocial and quality of life measures in people living with LBD and their caregivers. The intervention involves 3 supervised 1-h sessions per week (24 sessions in total) administered by an Accredited Exercise Physiologist in a clinical facility at the University of Sydney in Lidcombe, Australia.
Discussion: The PRIDE study is the first controlled trial to evaluate a robust exercise intervention within a LBD cohort and will provide crucial information required to inform robust future clinical trials.
Item ID: | 62887 |
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Item Type: | Article (Scholarly Work) |
ISSN: | 2451-8654 |
Keywords: | Dementia; exercise physiology; Lewy body; anabolic; protocol |
Copyright Information: | © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license |
Sensitivity Note: | n/a |
Date Deposited: | 29 Apr 2020 04:22 |
FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1106 Human Movement and Sports Science > 110602 Exercise Physiology @ 30% 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110308 Geriatrics and Gerontology @ 70% |
SEO Codes: | 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920502 Health Related to Ageing @ 20% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920112 Neurodegenerative Disorders Related to Ageing @ 20% 92 HEALTH > 9202 Health and Support Services > 920201 Allied Health Therapies (excl. Mental Health Services) @ 60% |
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