Extracellular vesicles as a target for the development of anti-helminth vaccines

Kifle, Desalegn Woldeyohannes, Sotillo, Javier, Pearson, Mark S., and Loukas, Alex (2017) Extracellular vesicles as a target for the development of anti-helminth vaccines. Emerging Topics in Life Sciences, 1 (6). pp. 659-665.

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There is a rapidly growing body of evidence that production of extracellular vesicles (EVs) is a universal feature of cellular life. More recently, EVs have been identified in a broad range of both unicellular and multicellular parasites where they play roles in parasite–parasite intercommunication as well as parasite–host interactions. Parasitic helminthderived EVs traverse host target cell membranes whereupon they offload their molecular cargo — proteins, lipids, and genetic information such as mRNAs and miRNAs — which are thought to hijack the target cell and modulate its gene expression to promote parasite survival. As such, EVs represent a novel mechanism of intercellular communication that could be targeted for vaccine-mediated interruption, given the abundance of surface antigens expressed on helminth EVs, and the ability of antibodies to block their uptake by target cells. In this Perspective article, we review recent developments in the field of helminth-derived EVs and highlight their roles in helminth vaccine discovery and development.

Item ID: 62879
Item Type: Article (Research - C1)
ISSN: 2397-8562
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Copyright Information: © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology.
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A version of this publication was included as Chapter 1 of the following PhD thesis: Kifle, Desalegn Woldeyohannes (2020) Schistosoma mansoni extracellular vesicles: immunobiology and vaccine efficacy. PhD thesis, James Cook University, which is available Open Access in ResearchOnline@JCU. Please see the Related URLs for access.

Date Deposited: 06 Aug 2020 01:38
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 50%
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