Influence of sympathetic activity in the control of peripheral microvascular tone in preterm infants

Corbisier De Meautsart, Celine, Dyson, Rebecca M., Latter, Joanna L., Berry, Mary J., Clifton, Vicki L., and Wright, Ian M.R. (2016) Influence of sympathetic activity in the control of peripheral microvascular tone in preterm infants. Pediatric Research, 80 (6). pp. 793-799.

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Background: Microvascular dysregulation following preterm birth is associated with increased illness severity and hypotension, particularly in males. Sympathetic nervous vascular regulation is evident in females. We hypothesized that sympathetic dysfunction in male preterm infants may contribute to a failure of peripheral microvascular vasoconstriction.

Methods: Microvascular blood flow of infants 24–43 wk gestational age was assessed at 6, 24, and 72 h of age by laser Doppler. Blood flow Fourier transformed frequency distribution spectra (low frequency/high frequency ratio) were used to assess the influence of sympathetic tone on microvascular regulation. Total sympathetic output was assessed as urinary normetanephrine.

Results: Microvascular sympathetic activity at 24 h postnatal age decreased in early preterm males, but not females. Peripheral sympathetic activity increased with advancing postnatal age in females, but decreased in males. In early preterm infants, total normetanephrine outputs increase significantly with postnatal age, in both sexes.

Conclusion: Sympathetic activation following preterm birth is sexually dimorphic, with preterm males having reduced sympathetic tone and reduced upregulation of sympathetic tone following birth. There is evidence of a disconnect between central sympathetic activity and local peripheral microcirculatory sympathetic drive. This may relate to autonomic nervous immaturity and highlights the need to understand how preterm birth may affect autonomic function.

Item ID: 62797
Item Type: Article (Research - C1)
ISSN: 1530-0447
Copyright Information: Copyright © 2016 International Pediatric Research Foundation, Inc.
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC project grant ID#569285
Date Deposited: 07 Jun 2022 03:36
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321303 Neonatology @ 100%
SEO Codes: 20 HEALTH > 2005 Specific population health (excl. Indigenous health) > 200506 Neonatal and child health @ 100%
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