Gut microbiota of preterm infants supplemented with probiotics: Sub-study of the ProPrems trial
Plummer, Erica L., Bulach, Dieter M., Murray, Gerald L., Jacobs, Susan E., Tabrizi, Sepehr N., Garland, Suzanne M., and ProPrems Study Group, (2018) Gut microbiota of preterm infants supplemented with probiotics: Sub-study of the ProPrems trial. BMC Microbiology, 18 (1). 184.
|
PDF (Published Version)
- Published Version
Available under License Creative Commons Attribution. Download (598kB) | Preview |
Abstract
Background: The ProPrems trial, a multi-center, double-blind, placebo-controlled randomized trial, previously reported a 54% reduction in necrotizing enterocolitis (NEC) of Bell stage 2 or more from 4.4 to 2.0% in 1099 infants born before 32 completed weeks’ gestation and weighing < 1500 g, receiving probiotic supplementation (with Bifidobacterium longum subsp. infantis BB-02, Streptococcus thermophilus TH-4 and Bifidobacterium animalis subsp. lactis BB-12). This sub-study investigated the effect of probiotic supplementation on the gut microbiota in a cohort of very preterm infants in ProPrems.
Results: Bifidobacterium was found in higher abundance in infants who received the probiotics (AOR 17.22; 95% CI, 3.49–84.99, p < 0.001) as compared to the placebo group, and Enterococcus was reduced in infants receiving the probiotic during the supplementation period (AOR 0.27; 95% CI, 0.09–0.82, p = 0.02).
Conclusion: Probiotic supplementation with BB-02, TH-4 and BB-12 from soon after birth increased the abundance of Bifidobacterium in the gut microbiota of very preterm infants. Increased abundance of Bifidobacterium soon after birth may be associated with reducing the risk of NEC in very preterm infants.
Item ID: | 62781 |
---|---|
Item Type: | Article (Research - C1) |
ISSN: | 1471-2180 |
Keywords: | Gut microbiota, Necrotizing enterocolitis, Probiotics, Very preterm infants |
Copyright Information: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Funders: | National Health and Medical Research Council (NHMRC) |
Projects and Grants: | NHRMC 454629 |
Date Deposited: | 27 Jul 2022 00:52 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321303 Neonatology @ 100% |
SEO Codes: | 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100% |
Downloads: |
Total: 657 Last 12 Months: 10 |
More Statistics |