Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume

O’Hara, Kate, Schneider, Jennifer J., Jones, Alison L., Wright, Ian M.R., Martin, Jennifer H., and Galettis, Peter (2019) Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume. Journal of Liquid Chromatography and Related Technologies, 42 (15-16). pp. 521-527.

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Abstract

Remifentanil is a short acting opioid currently used in anesthesia and as an analgesic. This paper describes a simple, fast HPLC-MS/MS methodology that allows detection of remifentanil in low volume plasma samples. Acetonitrile protein precipitation is used for sample extraction and clean up. The assay has a lower limit of detection of 0.25 ng/mL and a 3 min run time.

Item ID: 62777
Item Type: Article (Research - C1)
ISSN: 1520-572X
Keywords: HPLC-MS/MS, LC-MS/MS, microassay, neonate, pharmacokinetics, remifentanil
Copyright Information: © 2019 Taylor & Francis Group, LLC.
Date Deposited: 17 May 2020 22:15
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321405 Pharmaceutical sciences @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321499 Pharmacology and pharmaceutical sciences not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920501 Child Health @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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