Isotope metallomics approaches for medical research

Mahan, Brandon, Chung, Roger S., Pountney, Dean L., Moynier, Frédéric, and Turner, Simon (2020) Isotope metallomics approaches for medical research. Cellular and Molecular Life Sciences, 77. pp. 3293-3309.

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Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and perspectives from other “-omics” sciences (e.g. genomics, proteomics) and from research vocations further afield. Perhaps the most esoteric of this latter cat- egory has been the recent coupling of biomedicine with element and isotope geochemistry, commonly referred to as isotope metallomics. Over the course of less than two decades, isotope metallomics has produced numerous benchmark studies highlighting the use of stable metal isotope distribution in developing disease diagnostics—e.g. cancer, neurodegeneration, osteoporosis—as well as their utility in deciphering the underlying mechanisms of such diseases. These pioneering works indicate an enormous wealth of potential and provide a call to action for researchers to combine and leverage expertise and resources to create a clear and meaningful path forward. Doing so with efficacy and impact will require not only building on existing research, but also broadening collaborative networks, bolstering and deepening cross-disciplinary channels, and establishing unified and realizable objectives. The aim of this review is to briefly summarize the field and its underpinnings, provide a directory of the state of the art, outline the most encouraging paths forward, including their limitations, outlook and speculative upcoming breakthroughs, and finally to offer a vision of how to cultivate isotope metallomics for an impact- ful future.

Item ID: 62763
Item Type: Article (Research - C1)
ISSN: 1420-9071
Keywords: stable metal isotopes, metallomics, isotope metallomics, geochemistry, biomarkers, disease diagnostics, neurodegeneration
Copyright Information: © Springer Nature Switzerland AG 2020
Funders: Macquarie University
Projects and Grants: Deputy Vice Chancellor of Research discretionary funding
Date Deposited: 23 Jun 2020 19:50
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3299 Other biomedical and clinical sciences > 329999 Other biomedical and clinical sciences not elsewhere classified @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320599 Medical biochemistry and metabolomics not elsewhere classified @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 100%
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