The emerging role of vascular endothelial growth factor (VEGF) in vascular homeostasis: Lessons from recent trials with anti-VEGF drugs

Thanigaimani, Shivshankar, Kichenadasse, Ganessan, and Mangoni, Arduino A. (2011) The emerging role of vascular endothelial growth factor (VEGF) in vascular homeostasis: Lessons from recent trials with anti-VEGF drugs. Current Vascular Pharmacology, 9 (3). pp. 358-380.

[img] PDF (Publisher Accepted Version) - Accepted Version
Restricted to Repository staff only

View at Publisher Website: https://doi.org/10.2174/1570161117954955...
23


Abstract

Vascular endothelial growth factor (VEGF) is an endogenous polypeptide that modulates angiogenesis in normal physiological conditions as well as in cancer. During angiogenesis, VEGF interacts with several other angiogenic factors, playing an important role in cell proliferation, differentiation, migration, cell survival, nitric oxide (NO) production, release of other growth factors and sympathetic innervation. Based on these mechanisms of action, several anti-VEGF drugs have been developed for cancer treatment. This review discusses the physiology and interactions of VEGF, its mechanisms of action and role in modulating vascular homeostasis. It also discusses the adverse cardiovascular effects of recently developed anti-VEGF drugs for the treatment of various types of cancer. A critical appraisal of the human studies on these drugs is provided. Furthermore, putative mechanisms for the onset of hypertension, the most common adverse cardiovascular effect, are discussed.

Item ID: 62536
Item Type: Article (Research - C1)
ISSN: 1875-6212
Keywords: Angiogenesis, Cardiotoxicity, Clinical trials, Endothelium, Homeostasis, Hypertension, Nitric oxide, Vascular endothelial growth factor
Copyright Information: © 2011 Bentham Science Publishers Ltd.
Date Deposited: 19 Mar 2020 02:19
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page