Kokavec, Anna (2017) Effect of wine on postprandial serum insulin, plasma glucose, serum IgA and insulin sensitivity as all wines are not the same. Journal of Diabetes & Metabolism, 8 (Suppl 1).

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Abstract

Statement of the Problem: The effect of wine on glucose metabolism and utilization in non-diabetic individuals is largely unknown and requires investigation. The purpose of this study is to compare the effect of red and white wine on postprandial glucose metabolism and utilization in non-diabetic individuals.

Methodology & Theoretical Orientation: This study utilized a 3x4 mixed design. The 'between subjects' factor was trial (white wine, red wine, placebo) and the 'within subjects' factor was time (Food, 45-min, 90-min, 135-min). The experimental procedure required 24 nondiabetic males to consume food for 45-min and then ingest 4x standard units (40 g of alcohol) of white wine (n=8), red wine (n=8) or the equivalent amount of placebo (n=8) over a period of 135 minutes. Measures of serum insulin, plasma glucose and serum immunoglobulin A (IgA) were taken upon arrival (Baseline), after the meal (0 minutes) and during beverage consumption (45 minutes, 90 minutes and 135 minutes).

Findings: Significant trial differences were observed when data was compared. The level of postprandial: Plasma glucose was significantly reduced with red wine at 45 minutes (<13 g of alcohol); serum insulin was significantly reduced with white wine at 45 minutes (<13 g of alcohol); serum IgA became significantly elevated with white wine at 45 minutes (<13 g of alcohol). Moreover, a significant improvement in insulin sensitivity was only noted with white wine at 90 minutes (<30 g of alcohol).

Conclusion & Significance: Both red wine and white wine can alter postprandial glucose metabolism and utilization in non-diabetic individuals. However, the effect of red wine and white wine is not the same: white wine after a meal improves improve insulin sensitivity and promotes the development of a transient pseudo-diabetic condition; red wine after a meal alters the glucose-insulin feedback mechanism,reduces insulin sensitivity and promotes the development of a transient pseudo-hypoglycemic condition. Thus, consuming wine alone after a meal should not be encouraged in non-diabetics.

Item ID:	62511
Item Type:	Article (Abstract)
ISSN:	2155-6156
Keywords:	alcohol, insulin, feeding, wine, glucose, fasting
Additional Information:	Presented at the 16th Global Diabetes Conference & Medicare Expo, Milan, Italy, 22-23 March 2017
Date Deposited:	23 Mar 2020 23:36
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology @ 80% 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) @ 20%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920106 Endocrine Organs and Diseases (excl. Diabetes) @ 30% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920414 Substance Abuse @ 40% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 30%
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