Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control

Pearson-Dennett, Verity, Faulkner, Patrick L., Collie, Brittany, Wilcox, Robert A., Vogel, Adam P., Thewlis, Dominic, Esterman, Adrian, Mcdonnell, Michelle N., Gandevia, Simon C., White, Jason M., and Todd, Gabrielle (2019) Use of illicit amphetamines is associated with long-lasting changes in hand circuitry and control. Clinical Neurophysiology, 130 (5). pp. 655-665.

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Abstract

Objective: The study aim was to determine if use of illicit amphetamines or ecstasy is associated with abnormal excitability of the corticomotoneuronal pathway and manipulation of novel objects with the hand.

Methods: Three groups of adults aged 18–50 years were investigated: individuals with a history of illicit amphetamine use, individuals with a history of ecstasy use but minimal use of other stimulants, and non-drug users. Transcranial magnetic stimulation was delivered to the motor cortex and the electromyographic response (motor evoked potential; MEP) was recorded from a contralateral hand muscle. Participants also gripped and lifted a novel experimental object consisting of two strain gauges and an accelerometer.

Results: Resting MEP amplitude was larger in the amphetamine group (6M, 6F) than the non-drug and ecstasy groups (p < 0.005) in males but not females. Overestimation of grip force during manipulation of a novel object was observed in the amphetamine group (p = 0.020) but not the ecstasy group.

Conclusions: History of illicit amphetamine use, in particular methamphetamine, is associated with abnormal motor cortical and/or corticomotoneuronal excitability in males and abnormal manipulation of novel objects in both males and females.

Significance: Abnormal excitability and hand function is evident months to years after cessation of illicit amphetamine use.

Item ID: 62311
Item Type: Article (Research - C1)
ISSN: 1872-8952
Keywords: Methamphetamine; Ecstasy; Hand function; Transcranial magnetic stimulation; Motor cortex; Excitability
Copyright Information: © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved
Funders: Fay Fuller Foundation (FFF), National Health and Medical Research Council of Australia (NHMRC), Australian Government (AG), Clive and Vera Ramaciotti Foundation (CVRF), University of South Australia (USA)
Projects and Grants: FFF Discovery Fund Research Grant, NHMRC Senior Principal Research Fellowship, NHMRC Dementia Fellowship APP 1135683, NHMRC Career Development Fellowship ID 1126229, AG Research Training Program Scholarship, CVRF Establishment Grant ID 2974/2010, USA School of Pharmacy and Medical Sciences – Partial PhD Scholarship, USA Top-Up Scholarship
Date Deposited: 18 Feb 2020 23:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9205 Specific Population Health (excl. Indigenous Health) > 920599 Specific Population Health (excl. Indigenous Health) not elsewhere classified @ 100%
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